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Edward younglai2


Dr Younglai obtained his PhD from McGill University on work related to the metabolism of 16a-hydroxysteroids in man. He then spent two years of postdoctoral work with Dr Roger Short in Cambridge, England where he introduced the two-cell theory of ovarian steroidogenesis using the horse follicle as a model.

On his return to Canada he joined the department of Obstetrics and Gynecology at McMaster University where he has supervised the research of a number of Masters and Doctoral students. He has made many contributions to the hormonal changes during the estrous cycle and pregnancy of domestic animals and other exotic species such as the bat.

He has actively participated in over a dozen committees and is/was on numerous professional organizations, such as the Canadian Fertility and Andrology Society, Society for the Study of Reproduction, the American Society for Reproductive Medicine and the European Society for Human Reproduction and Embryology, including being President of Canadian Investigators in Reproduction for a year.

He has over 190 publications in peer reviewed journals, held research grants from a number of agencies over the years including CIHR. He reviews manuscripts for journals and applications for grant awards. He is Editor-in-Chief of “Reproductive Biology Insights” and an associate editor of “Human Reproduction”.

Research Interests

Dr YoungLai is interested in many aspects of the control of fertility and in particular the effects of environmental toxicants on gonadal function. His recent research was focused on the nongenomic (rapid) effects of ovarian steroids and insecticides, an emerging area of intense scientific interest.

Featured Publications

  • Younglai, E.V. Editorial. Reprod Biol Insights 2: 23-24, 2009
  • Younglai, E.V. Pollutants, sedentarism, circadian rhythm and their effects on fertility. Reprod Biol Insights 2: 47-52, 2009
  • MS Neal MS, Reade CJM, Younglai EV, Holloway AC. Goodrow GJ. Granulosa cell aromatase activity in patients undergoing IVF: A comparison of good and poor responders. JSOGC 30:138-142. 2008.
  • Neale MS, Foster WG, Younglai EV. The detrimental effects of smoking on IVF success. Curr Womens Health Rev 4:16-24 (invited review). 2008.
  • Price TM, Murphy S, Younglai EV. Perspectives: the possible influence of assisted reproductive technologies on transgenerational reproductive effects of environmental endocrine disruptors. Toxicol Sci. 96:218-26.Review. 2007.
  • Younglai EV, Wu Y, Foster WG. Reproductive toxicology of environmental toxicants: emerging issues and concerns. Curr Pharmaceut Design 13: 3005-3019. (invited review). 2007.
  • Holloway AC, Petrik JJ, Younglai EV. Influence of dichlorodiphenylchloroethylene on vascular endothelial growth factor and insulin-like growth factor in human and rat ovarian cells. Reprod Toxicol. 24:359-364. 2007.
  • Wu YJ, Foster WG, Younglai EV. Rapid action of pesticides on human granulosa-lutein cells. Reproduction 131: 299-310, 2006.
  • Younglai EV, Wu YJ, Foster WG. Rapid action of pesticides on cytosolic calcium concentrations in cultures of human umbilical vein endothelial cells. Reprod Toxicol 21: 271-279, 2006.
  • Foster WG, Neal MS, Younglai EV. Ovarian toxicity of environmental toxicants. Immunol Endocrinol Metab Agents Med Chem. 6: 37-43, 2006.
  • Younglai EV, Wu YJ, Foster WG. Do insecticides have adverse effects on reproduction? Immunol Endocrinol Metab Agents Med Chem. 6: 45-56, 2006.
  • Lobb DK and Younglai EV. A simplified method for preparing IVF granulosa cells for culture. J Assist Reprod Gen 23(2): 93-95. doi:10.1007/s10815-006-9025-5 2006.
  • Younglai EV, Wu YJ, Foster WG, Lobb DK, Price TM. Binding of progesterone to cell surfaces of human granulosa-lutein cells. J Steroid Biochem Mol Biochem 101, 61-67 2006.
  • Younglai EV. Environmental factors influencing ART success. Embryo Talk 1(4), 185-192. (invited review). 2006.
  • Younglai EV, Holloway AC, Foster WG. Environmental and occupational factors affecting fertility and IVF success. Hum Reprod Update 11:43-57, 2005.
  • Younglai EV, Wu YJ, Kwan TK, Kwan C-Y. Non-genomic action of estradiol and progesterone on cytosolic calcium concentrations in primary cultures of human granulosa-lutein cells. Hum Reprod 20: 2383-2390, 2005.
  • Foster WG, Younglai EV, Boutross-Tadross O, Hughes CL, Wade MG. Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein. Toxicol Sci 77:91-100, 2004. .
  • EV Younglai, TK Kwan, C-Y Kwan, DK Lobb, WG Foster. Dichlorodiphenylchloroethylene elevates cytosolic calcium concentrations and oscillations in primary cultures of human granulosa-lutein cells. Biology of Reproduction 70:1693-1700, 2004.
  • EV Younglai, AC Holloway, GE Lim, WG Foster. Synergistic effects between follicle stimulating hormone and 1,1-Dichloro-2,2-bis(p-Chlorophenyl)-Ethylene (p,p’-DDE) on human granulosa cell aromatase activity. Human Reproduction 19:1089-1093, 2004.
  • WG Foster, EV Younglai, O Boutross-Tadross, CL Hughes, MG Wade. Mammary gland morphology in Sprague-Dawley rats following treatment with an organochlorine mixture in utero and neonatal genistein. Toxicol. Sci. 77:91-100, 2004.
  • MS Neal, EV Younglai, AC Holloway, WG Foster. Aromatase activity in granulosa cells as a predictor of pregnancy potential. Intl Congr Ser. Res Papers Fertil Reprod Med. 1271:139-142, 2004.
  • Foster WG, Neal MS, Younglai EV. Endocrine disrupters and ovarian function. Intl Congr Ser. Adv Fertil Reprod Med. 1266:126-132, 2004.
  • A Revel, H Raanani, E Younglai, J Xu, I Rogers, R Han, J-F Savouret, RF Casper. Resveratrol, a natural aryl hydrocarbon receptor antagonist, protects lung from DNA damage and apoptosis caused by benzol[”]pyrene. J Appl Toxicol 23:255-261, 2003.
  • Younglai EV, Foster WG. Dichlorodiphenylchloroethylene and human fertility. ART and Science 3:6-8, 2003.
  • MG Wade, WG Foster, EV Younglai, A McMahon, K Leingartner, A Yagminas, D Blakey, M Fournier, D Desaulniers and CL Hughes. Effects of subchronic exposure to a complex mixture of persistent contaminants in male rats: Systemic, immune, and reproductive effects. Toxicological Sciences 67: 131-143, 2002.


  • PhD - McGill University 

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