The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from the scientific community to support outstanding research in the area of trophoblast differentiation and function in relation to fertility and pregnancy, including the role of the immune system. It is anticipated that fundamental knowledge gained by this research will act as a solid foundation to hasten treatments for a number of placental-based pregnancy disorders, such as implantation failure, frequent pregnancy loss, preeclampsia, fetal growth restriction, and preterm birth.
A major goal of this FOA is to stimulate research that will broaden our understanding of how trophoblast cells differentiate and function with respect to their interaction with maternal cells/tissues. Starting from the time of blastocyst implantation through placentation, trophoblast cells interact with uterine luminal epithelium, stromal cells, decidual cells, immune cells, blood vessels and other uterine components. Research on human trophoblast is ideal; experimental animal studies are acceptable to enhance our understanding of human trophoblast differentiation and function.
R01 - Research Grant - no fixed budget, 1-5 years Due: Feb 5, June 5, Oct 5
R21 - Exploratory/Developmental Research Grant - $275,000 over 2 years. Due Feb 16, June 16, Oct 16
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